Ridker PM, Rifai N, MacFadyen J, Glynn RJ, Jiao L, Steg PG, Miller M, Brinton EA, Jacobson TA, Tardif JC, Ballantyne CM, Mason RP, Bhatt DL (2022) Effects of randomized treatment with icosapent ethyl and a mineral oil comparator on interleukin-1, interleukin-6, c-reactive protein, oxidized low-density lipoprotein cholesterol, homocysteine, lipoprotein(a), and lipoprotein-associated phospholipase a2: a reduce-it biomarker substudy
Increased growth hormone and IGF-1 levels are among the most commonly cited benefits and may support cell repair, tissue regeneration, and fat regulation
Limitations Current pharmacological strategies for managing inflammation include corticosteroids, disease-modifying antirheumatic drugs (DMARDs), biologics, and non-steroidal anti-inflammatory drugs (NSAIDs)
Age: Glutathione levels naturally decrease with age, which can impair detoxification, immunity, and antioxidant protection
The 4.5 mg dose produced 10.8% mean weight loss at 26 weeks