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Antibiotic-induced gut microbe dysbiosis alters neurobehavior in mice through modulation of BDNF and gut integrity

Anti-drug antibodies may develop against therapeutic peptides, particularly those that differ structurally from endogenous human peptides

The compound 5 amino 1mq has the chemical name 5-amino-1-methylquinolinium, a small molecule methylquinolinium derivative with amino substitution at position 5

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Previous studies have shown that opioids inhibit colonic motility primarily via peripheral MOR activation 33,56 and that both the small intestine and the colon receive vagal innervation from the DMV 57,58