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There are concerns about the development of diabetes and metabolic syndrome with long-term use

"An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19"

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[DOI] [PMC free article] [PubMed] [Google Scholar] 403.Hirayama, A

This remains an actively moving area, however: on February 27, 2026, the HHS Secretary publicly announced an intent to move roughly 14 of the 19 Category 2-listed peptides, reportedly including ipamorelin and CJC-1295, back toward Category 1 status, and multiple industry and legal-news outlets reported further FDA action in the following months easing Category 2-related restrictions on this group of peptides