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These diverse and interconnected functions underscore the critical importance of mitochondria in maintaining cellular health and homeostasis, and perturbations in these processes have been linked to a wide range of diseases, including cardiovascular disorders and cognitive impairments, highlighting the need for further research into mitochondrial function and dysfunction

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Among neonates, 60%74% undergoing ECMO have AKI and, in a cohort study of adults treated with ECMO (92), the estimated incidence of AKI and severe AKI requiring renal replacement therapy (RRT) was 62.8% and 44.9% (93), respectively

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