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As with any hormone-related therapy, a full health assessment including a baseline hormone panel is essential before starting, particularly for women of reproductive age or those approaching menopause

Reactive oxygen species (ROS) and other free radicals can damage cellular components, including lipids, protein and DNA

Importantly, the prevalence of adverse effects does not appear to differ from that observed in patients with T2DM treated with GLP-1 RAs

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9 Conclusion In summary, flavonoids constitute a promising multi-target therapeutic platform for AD, providing a robust mechanistic foundation for translational advancement