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These medications may be acting on the knee through three simultaneous routes: reducing mechanical stress, protecting joint tissue directly and alleviating the pain that drives surgical decision-making. F&B takeaway: Whats important here is the ripple effect, says Circanas Lyons Wyatt

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[It creates] an unhealthy feedback loop: The thing they need to do to help control their pain is too painful for them to do. The Benefits of GLP-1 Drugs By helping patients lose weight, GLP-1s may enable them to have a surgery that could restore their movement and reduce their pain enough to be able to resume exercise