In Latin America, where obesity rates have grown faster than in other parts of the world, the drug remains unaffordable for the bulk of the population
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Mechanistic hypotheses: Some studies investigate whether biased signaling, altered -arrestin recruitment, or receptor trafficking patterns change downstream signaling profiles

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Antibodies are hydrolyzed by proteases into peptides or amino acids, which are then progressively broken down into components relevant to the payload to exert efficacy