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Since 2005, multiple GLP-1R agonists resembling exendin-4 have been developed ( Figure 2 ), with fatty-acid modifications to increase half-life and facilitate less frequent dosing regimes

While transdermal patch delivery systems are under investigation, all commercially available GLP-1 therapies require subcutaneous injection (semaglutide, liraglutide, dulaglutide, tirzepatide) or oral administration (Rybelsus)

But it also reported complete weight regain after two years in: It takes a lot of effort to keep that weight off once you stop taking a GLP-1, says Dr

While this early research was done with animals, the results are promising

some patients have documented conditions they did not know about, and some have BMI in a range we can revisit at a future visit