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Mice in both groups were fasted for 12 hours at the ages of 12, 16, and 20 weeks, and were anesthetized with sevoflurane (Wako, Osaka, Japan), followed by blood and tissue collection at the end of the experiment
KennedyDOStevensonEJJacksonPADunnSWishartKBieriGet al
An IM dose administered SubQ will take 23 longer to reach peak plasma levels (34 hours vs 6090 minutes) and will produce lower Cmax but sustained elevation over 68 hours instead of clearing by hour 4
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