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The size of the ovary reduces to one-third or even more

In addition to investigating the effects of Setmelanotide on body weight and hunger, researchers also examined quality of life (QOL) and depression scores of participants using the disease-specific Impact of Weight on Quality of Life-Lite (IWQOL-Lite) self-report measure for patients 18 years of age, the age-appropriate Pediatric Quality of Life Inventory (PedsQL) for those under 18 years of age, and the Patient Health Questionnaire-9 (PHQ-9)

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Reducing the fat load improves the ratio of function to body weight even if some absolute lean mass is lost along the way