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GPx-1 can also reduce lipid hydroperoxides and other soluble hydroperoxides after their release from membrane lipids (248, 257), and may also reduce phospholipid-monoacylglycerol hydroperoxides, such as 1-linoleoyl lysophosphatidylcholine hydroperoxide (247), but not tri- or diacylglycerol hydroperoxides (247)

A 2019 study in Photochemistry and Photobiology found that doses above 0.6mg daily in type III subjects increased melanin optical density by less than 5% compared to 0.5mg daily, while nausea incidence rose from 18% to 34%