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None of these endpoints has been validated against clinical outcomes for GLP-1R agonists specifically, and EVOKE is the cautionary case of how readily a biomarker shift and a clinical result can be conflated

Apnea events (breathing pauses per hour) decline gradually as weight decreases, with the most dramatic improvements appearing after 3-6 months of consistent use

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GLP-1 is a natural hormone released by the intestines during meals that helps control appetite, leading to weight loss and improvements in blood pressure and cholesterol