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Higher incidence of anemia Complications in Pregnancy Due To Neural Tube Defects, posterior Tongue tie, lip tie Anencephaly Other neural tube defects Spina bifida Autism Rheumatoid Arthritis Flares Down Syndrome PEs Altered drug metabolism Low vitamin d levels/ osteoporosis Neuropsychiatric Disorders Gestational Diabetes Early Pregnancy Loss/ SAB (viable fetus) Placental Abruption, Low Birth Weight The most common MTHFR gene mutations are found at position 677 and/or position 1298 on the MTHFR gene

Clinical complications, such as liver cirrhosis, hepatocellular carcinoma, diabetes, cardiomyopathy, hypogonadism, arthropathy, and osteoporosis, may occur [65]