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Human leptin deficiency was associated with early-onset morbid obesity and metabolic syndrome without SNS activation or hypertension (Ozata et al., 1999)
The investigators reported that NNMT knockdown produced protection from diet-induced obesity and increased adipocyte energy expenditure, establishing the genetic precedent for the 5-Amino-1MQ pharmacological program
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Midzak AS, Chen H, Aon MA, Papadopoulos V, Zirkin BR
2011;471(7339):S101
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