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PICOs question The primary research question addressed in this review was: What is the effectiveness of sublingual/oral administration of Vitamin B12 alone or compared to other forms of administration (e.g., intramuscular injection)?

doi: 10.1016/j.clim.2020.108480 155 GuoYKortewegCMcNuttMAGuJ

The recovered COVID-19 group had remarkably decreased tryptophan levels, hyperactive monocytes that are spitting out inflammatory mediators (sCD14/sCD163), high levels of inflammatory lipid byproducts, altered metabolic gene expression, activated inflammasomes, higher caspase-1/4/5 activity and plasma IL-1 levels, increased T-cell activation, and increased oxidative stress