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Pregnancy as a window to future health: excessive gestational weight gain and obesity

While data specific to GLP-1 RA discontinuation remain limited, a large-scale prospective study on weight cycling (mean age 63.6 years, at high risk of T2DM) reported that weight regain was typically characterized by an adverse shift in body composition, with FM returning to baseline levels while FFM declined by 1.50 kg (95% CI 0.662.35)

The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke

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In 2023, NICE issued similar guidance for semaglutide, although this time, the duration of treatment was restricted to a maximum of two years and the drug could only be provided within a specialist weight management service