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Insulin resistance is linked to several negative consequences, such as endothelial dysfunction, reduced cardiac diastolic relaxation, impaired vascular relaxation, decreased coronary blood flow, and increased susceptibility to ischemia

pmid:11890482

In adults, IGF-1 is produced primarily in the liver and to a lesser extent in the hippocampus, cerebellum, and subventricular zone-olfactory bulb (SVZ-OB) under stimulation of growth hormone (GH) [19]

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Other studies explored individuals with depression