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Pollock RF, Norrbacka K, Cameron C, Mancillas-Adame L, Jeddi M

Patients with hepatic steatosis, visceral adiposity, or reduced energy expenditure may particularly benefit from agents with GCGR activity (such as GLP-1/glucagon or triple GLP-1/GIP/glucagon agonists), which enhance lipid oxidation and thermogenesis

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The C allele alone has minimal physiological impact, but when combined with C677T, it reduces MTHFR activity and folate levels, raising homocysteine

in preclinical and in-vitro systems it has been studied as a GHRH-receptor agonist on anterior pituitary cells, where it has been observed to stimulate the synthesis and pulsatile release of endogenous growth hormone