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The BBB has an active Pattern of Complaints alert covering the exact issues I ran into

[1] [3] Rapid or excessive infusions can disturb electrolytes or cause fluid overload, though this is rare with proper dosing and monitoring

Review and strengthen prescriber documentation

Of note, the majority of cutaneous melanomas arise within normally appearing skin

Unfortunately, the design of this trial did not include a monotherapy infliximab arm, so there is no way to know whether the addition of methotrexate led to greater improvement than would have been achieved with infliximab alone