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10.1038/s41568-021-00378-6 132 Martn-RufinM.Nascimento-GomesR.HigueroA.CrismaA

This outcome suggests a positive impact on the Ubiquitin Proteasome System

Histological features Atypical nevi on the scalp are characterized by asymmetry and poor lateral circumscription (Figs 25.7025.74)

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This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]