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These processes regulate metabolism and inflammation through the PDE3-AMPK-glycolysis pathway and the Wnt/-catenin-glycolysis axis, respectively (Krause et al., 2024
TGF-, transforming growth factor beta
164 In addition, hyperglycemia and other metabolic disorders such as dyslipidemia, inflammatory factors, excess IAPP and alterations in the gut microbiota, combine to contribute to IR and/or cell dysfunction through the common pathways of inflammation, ERS and oxidative stress (Fig