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This effect is likely driven by the prolonged circulating half-lives of long-acting and ultra-long-acting GLP-1RAs, such as semaglutide (via fatty acid acylation) and dulaglutide (via Fc fragment fusion), which maintain sustained GLP-1 receptor stimulation and enhance intestinal motility, thereby increasing diarrhea risk

Ibuprofen does not directly reduce tirzepatide's weight-loss effectiveness, but chronic NSAID use can worsen nausea or gastrointestinal side effects that tirzepatide users already experience

Gpx5 is an important antioxidant enzyme involved in the regulation of oxidative stress in the epididymis and plays key roles in the storage, maturation, and transport of sperm cells

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