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Studies of individual with both SNPs (C677T and A1298C) showed that subjects with heterozygosity for both mutations resulted in an even lower MTHFR activity than heterozygosity for single MTHFR mutations, while no subjects carry both homozygote for MTHFR mutations regardless which SNPs 15 Furthermore, There were studies of multiple polymorphisms of one-carbon metabolism and schizophrenia symptoms showed an increase negative symptoms severity with increase of risk alleles, suggesting a cumulative effects of risk SNPs in one-carbon metabolism 61
Decreased concentrations of folate and vitamin B12 were associated with poor clinical profiles of children with ASD
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La L-carnitine joue un rle essentiel dans le transport des acides gras longue chaine vers les mitochondries o ils peuvent tre oxyds pour produire de lnergie sous forme dadnosine triphosphate (ATP)
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