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Multiple observational studies have found that individuals with low B12 are significantly more likely to report depressive symptoms, and intervention studies show that correcting the deficiency improves mood outcomes sometimes substantially

Outside of that group, published safety data is essentially absent

This dual benefit underscores how the RSM can integrate both positive recoveries and negative removals, reframing contaminant treatment as part of the resource hierarchy 4,30,49

- Liver enzymes if any preexisting liver concern, given the monkey toxicology signal

It remains a research-phase compound that has not undergone the testing required to establish safety and efficacy in people