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Pheomelanin is lighter in color (yellow-red), so, an increase in the proportion of pheomelanin is associated with lighter skin color

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Dodson JA, Arnold SV, Gosch KL, Gill TM, Spertus JA, Krumholz HM , Rich MW, Chaudhry SI, Forman DE, Masoudi FA, Alexander KP

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These studies demonstrate that a genetically determined higher body mass index (BMI) is causally associated with an increased susceptibility to MS, with this effect being observed both in the adult population (176) and, more specifically, in pediatric-onset disease (177)