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The doses studied in clinical trials range from 1mg to 12mg, with 12mg being the highest dose tested and producing the greatest weight loss (-24.2% at 48 weeks in Phase 2, -28.7% at 68 weeks in Phase 3)

As evidenced in the SURPASS trials, this novel GIP/GLP-1 dual-acting hormone therapy is yielding significant improvements in A1c and weight loss

Acta Neuropathologica, 133 (2), 245261

The Bottom Line While Contrave and Wegovy reduce appetite and prompt weight loss, they reach their destination via different routes

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