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In vitro barrier models using Caco-2 cells (gut epithelium) or brain endothelial cells could be employed to test the hypothesis that microbiota metabolites, such as butyrateeither administered directly or derived from patient-derived fecal microbiota culturescan strengthen epithelial and endothelial barrier function and reduce oxidative stress [40]

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In a recent study, the ophthalmic drug N-acetyl carnosine (NAC) showed potential for the non-surgical treatment of early age-related cortical cataract and PSC after controlling for age, gender and daily activities